Journal article
Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
M Udawela, E Scarr, S Boer, JY Um, AJ Hannan, C McOmish, CC Felder, EA Thomas, B Dean
Npj Schizophrenia | NATURE PUBLISHING GROUP | Published : 2017
Abstract
Our previous study demonstrated that phospholipase C beta 1 mRNA was down-regulated in Brodmann's area 46 from subjects with schizophrenia. However, phospholipase C beta 1 protein has also been shown to be lower in Brodmann's area 8 and 9 from teenage suicide subjects, creating a potential confound in interpreting the findings in schizophrenia due to the high suicide rate associated with this disorder. To begin to reconcile and consolidate these findings, in this study, we measured mRNA and protein levels of phospholipase C beta 1 variants a and b in Brodmann's area 46 and Brodmann's area 9 from subjects with schizophrenia, many of whom were suicide completers, and determined the diagnostic ..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
The authors thank Mr Geoff Pavey for his curation of the post-mortem human tissue, and Miss Susan Juzva and Miss Thien-Kim Le for their technical assistance. Tissues were received from the Victorian Brain Bank Network. The study was supported by Operational Infrastructure Support from the Victorian State Government. This work was supported by the funding grants; NIH RO1 MH069696-01 and NHMRC project grant 3503441. Prof Dean is a NHMRC Senior Research Follow (400016). A/Prof Scarr was the Royce Abbey Post-Doctoral Fellow and an ARC future Fellow (FT100100689). Prof Hannan is an ARC Future Fellow (FT100100835).